Reversal of the Alzheimer disease

The Alzheimer disease affects 8% of the population after 65 years.

The Alzheimer disease is caused by an abnormal accumulation of certain proteins in the brain, causing the death of brain cells. There is currently no known treatment for the Alzheimer disease.

For about a decade, however, purpose designed light therapy is appearing as capable of causing the regression of the Alzheimer disease.

A significant regression occurs thanks to light stimulation at a frequency of 40 Hz, using blue light at a determined wavelength.  It should be noted that Blue light is being used for years by the PSiO technology to stimulate the neurons.

PSIO 3.0 glasses were designed in accordance with the conclusions and recommendations of the most recent academic studies on the Alzheimer disease.

Articles

• Stimulating the brain at 40 Hz to treat Alzheimer’s disease.
  What if exposure to 40 Hz light and sound could promote a healthier brain? That’s the hypothesis of scientists at The Picower Institute for Learning and Memory at Massachusetts Institute of Technology (MIT).
• 40Hz : la fréquence que le cerveau adore et qui lutte contre Alzheimer.
  Une fréquence particulière, de 40 Hz joue un rôle central dans les fonctions cérébrales. le cerveau marche au mieux avec cette fréquence et elle lutte contre Alzheimer.
• Stimulating the brain at 40 Hz to treat Alzheimer’s disease.
  What if exposure to 40 Hz light and sound could promote a healthier brain? That’s the hypothesis of scientists at The Picower Institute for Learning and Memory at Massachusetts Institute of Technology (MIT).
• The Idea Behind Using Masked 40 Hz, Light Based Brain Stimulation for Alzheimer Disease.
  Marcus Carstensen, PhD candidate, CTO and co-founder of OptoCeutics in Copenhagen, Denmark, talked about the mechanisms of using noninvasive light technologies for Alzheimer disease treatment.

Studies

• Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model.
  Lianne Hoeijmakers, Silvie R Ruigrok, Anna Amelianchik, Daniela Ivan, Anne-Marie van Dam, Paul J Lucassen, Aniko Korosi.
  This indicates that, at least in a genetic context, ES could aggravate AD pathology.
• Gamma Frequency Inhibits the Secretion and Aggregation of Amyloid-β and Decreases the Phosphorylation of mTOR and Tau Proteins in vitro.
  Yuan-Han Yang, Sun-Wung Hsieh, Hsi-Wen Chang, Jia-Li Sung, Chih-Pin Chuu, Chen-Wen Yen, Tzyh-Chyuan Hour.
  Our study showed 40 Hz gamma frequency involved in the inhibition of secretion and aggregation of Aβ and inhibition of p-Tau protein expression through the mTOR/4E-BP1/Tau signaling pathway.
• Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer's disease : results show that exercising in a 40-Hz light flickering environment may improve cognitive functioning by reducing Aβ and tau levels, thereby enhancing mitochondrial function and neuroplasticity.
  Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Hyun-Sik Kang, Dong-Hyun Kim, Seung-Soo Baek, Tae-Woon Kim.
• Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice.
  Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim.
  Exercising in a 40-Hz light flicker environment was more effective than exercise or 40-Hz light flicker alone. This synergistic effect may prevent cognitive dysfunction by inhibiting Aβ, tau pathway, and neuroinflammation and enhancing neuroplasticity and mitochondrial functions in the hippocampus during early Alzheimer's disease.
• 40 Hz Light Flicker Promotes Learning and Memory via Long Term Depression in Wild-Type Mice.
  Tian Tian, Xin Qin, Yali Wang, Yan Shi, Xin Yang.
• Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy (AlzLife).
• 40-Hz steady state response in Alzheimer's disease and mild cognitive impairment.
  J.A. van Deursen, E.F.P.M. Vuurman, V.H.J.M. van Kranen-Mastenbroek, F.R.J. Verhey, W.J. Riedel.